Organic Acids (Urine)
The Organic Acid Test (OAT) is a comprehensive assessment for a wide variety of biomarkers related to yeast (candida) and bacteria toxicity – specifically clostridia bacteria. It also evaluates oxalate toxicity, as well as mitochondria function, and various markers for vitamin and neurotransmitter problems. The Organic Acid Test includes a section for amino acid metabolites which can detect inborn errors of metabolism.
The citric acid cycle (Kreb’s cycle) in the mitochondrion, for example, comprised of nine organic acids and eight enzymes, is the central metabolic pathway for all fuel molecules; dietary carbohydrates, proteins, and fats. Deficiencies in any of the Kreb’s cycle enzymes causes an inefficient cycling of the acid intermediates – any number of which consequently increase in the urine of the affected individual. Metabolic defects such as these are commonly known as organic acidurias; a well established group of disorders classified under the term of Inborn Errors of Metabolism (IEM’s). In these patients, urinary organic acid profiling reveals elevated excretion of acid intermediates due to a block in a metabolic pathway; a block which may arise from a defect in the required enzyme or transport protein of the pathway in question.
Overall, the Organic Acid Test is simple to use (urine collection) and is a foundational test that should be considered for anyone dealing with a chronic health problem. Doctors often use this test for people with autism, mental health problems, fatigue, autoimmune disorders, cancer, poor sleep, etc.↑